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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MED1
All Species:
26.67
Human Site:
S588
Identified Species:
53.33
UniProt:
Q15648
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q15648
NP_004765.2
1581
168478
S588
S
I
K
D
R
H
E
S
V
G
H
G
E
D
F
Chimpanzee
Pan troglodytes
XP_001172395
1581
168474
S588
S
I
K
D
R
H
E
S
V
G
H
G
E
D
F
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_537654
1583
168625
S588
S
I
K
D
R
H
E
S
V
G
H
G
E
D
F
Cat
Felis silvestris
Mouse
Mus musculus
Q925J9
1575
167122
S588
S
I
K
D
R
H
E
S
V
G
H
G
E
D
F
Rat
Rattus norvegicus
NP_001127833
1567
166392
S573
S
I
K
D
R
H
E
S
V
G
H
G
E
D
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521297
422
46589
Chicken
Gallus gallus
XP_418125
1594
169410
S600
S
M
K
E
R
H
D
S
V
G
H
G
E
D
F
Frog
Xenopus laevis
Q6INP8
1570
165663
S569
G
M
K
E
R
H
D
S
T
G
H
G
D
D
F
Zebra Danio
Brachydanio rerio
XP_700209
1694
176982
M575
F
Q
G
P
I
T
S
M
F
N
M
G
P
M
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VP05
1475
149513
C518
V
I
Y
K
L
L
K
C
W
D
E
E
H
E
F
Honey Bee
Apis mellifera
XP_395879
1811
193227
Q592
S
Q
Q
Q
Q
Q
Q
Q
P
Q
Q
Q
P
F
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786427
2421
258175
D610
Q
S
H
S
I
L
S
D
L
T
T
T
M
S
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
N.A.
98
N.A.
94.4
93.9
N.A.
24.4
87.6
72.5
56.4
N.A.
22
24.4
N.A.
25.7
Protein Similarity:
100
100
N.A.
98.9
N.A.
97.1
96.5
N.A.
25.7
93.5
81.7
69
N.A.
38.9
41.1
N.A.
38.5
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
0
80
60
6.6
N.A.
13.3
6.6
N.A.
0
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
0
100
86.6
6.6
N.A.
26.6
26.6
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
42
0
0
17
9
0
9
0
0
9
59
0
% D
% Glu:
0
0
0
17
0
0
42
0
0
0
9
9
50
9
0
% E
% Phe:
9
0
0
0
0
0
0
0
9
0
0
0
0
9
67
% F
% Gly:
9
0
9
0
0
0
0
0
0
59
0
67
0
0
0
% G
% His:
0
0
9
0
0
59
0
0
0
0
59
0
9
0
0
% H
% Ile:
0
50
0
0
17
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
59
9
0
0
9
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
9
17
0
0
9
0
0
0
0
0
9
% L
% Met:
0
17
0
0
0
0
0
9
0
0
9
0
9
9
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% N
% Pro:
0
0
0
9
0
0
0
0
9
0
0
0
17
0
0
% P
% Gln:
9
17
9
9
9
9
9
9
0
9
9
9
0
0
9
% Q
% Arg:
0
0
0
0
59
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
59
9
0
9
0
0
17
59
0
0
0
0
0
9
0
% S
% Thr:
0
0
0
0
0
9
0
0
9
9
9
9
0
0
0
% T
% Val:
9
0
0
0
0
0
0
0
50
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% W
% Tyr:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _